Aldose Reductase Pathway
Aldose reductase inhibitory activity.
Aldose reductase pathway. Aldose reductase catalyzes the nadph dependent conversion of glucose to sorbitol the first step in polyol pathway of glucose metabolism. Role of aldose reductase ar in hyperglycemia induced oxidative stress. Excessive amount of glucose is shunted to the polyol pathway where ar reduces. Also called the sorbitol aldose reductase pathway the polyol pathway is a two step process that converts glucose to fructose.
In this pathway glucose is reduced to. Aging men and women display both increased incidence of cardiovascular disease and complications of myocardial infarction and heart failure. We hypothesized that. In the polyol pathway aldose reductase ar catalyzes the metabolism of glucose to sorbitol and sorbitol dehydrogenase catalyzes the metabolism of sorbitol to fructose.
Polyol pathway scheme depicting both the nadph dependent reduction step catalyzed by aldose reductase and the nad induced oxidation catalyzed by sorbitol dehydrogenase. Srinivasan in handbook of nutrition diet and the eye 2014.
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